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The short answer

The STEP 1 extension observed substantial regain after semaglutide and structured lifestyle support were withdrawn.

Why the context matters

The analysis followed 327 participants for a year after treatment ended. It was exploratory and involved a subset, rather than the full randomized trial.

What remains uncertain

The study does not tell us what every person will experience, or isolate stopping medication from stopping the structured lifestyle program. It is not a test of every possible maintenance approach.

PUT IT IN CONTEXT

Semaglutide: the reference

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Open the reference

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  1. 01

    Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension

    Wilding JPH et al. · Diabetes, Obesity and Metabolism · 2022

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